WebMar 21, 2024 · The spectrum of bladder cancer includes non-muscle invasive (superficial), muscle invasive, and metastatic disease, each with its own clinical behavior, biology, prognosis, and treatment. The clinical presentation, diagnosis, and staging of bladder cancer will be presented here. WebSquamous cell bladder cancer is a malignancy that can develop as a result of chronic irritation and swelling in the lining of the bladder. When chronic irritation occurs, the normally long and thin transitional cells that line the bladder can gradually change to squamous cells, which are flat and scale-like.
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WebDespite comprehensive genomic analyses, no targeted therapies are approved for bladder cancer. Here, we investigate whether a single and combination therapy with targeted agents exert antitumor effects on bladder cancer cells through genomic alterations using a three-dimensional (3D) high-throughput screening (HTS) platform. Seven human bladder … WebDec 23, 2014 · For many years, molecular understanding of bladder cancer biology has lagged behind that of other solid cancers, and this has represented a major barrier to … smart goals for administrators
Bladder Cancer Johns Hopkins Medicine
WebINTRODUCTION. Worldwide, cancer of the urinary bladder accounts for approximately 570,000 new cases and over 200,000 deaths annually [].Although there have been improvements in detection, treatment, and surveillance of bladder cancer, the overall prognosis for resectable bladder cancer has not improved [].Although molecular … Bladder cancer is a common type of cancer that begins in the cells of the bladder. The bladder is a hollow muscular organ in your lower abdomen that stores urine. Bladder cancer most often begins in the cells (urothelial cells) that line the inside of your bladder. Urothelial cells are also found in your … See more Bladder cancer signs and symptoms may include: 1. Blood in urine (hematuria), which may cause urine to appear bright red or cola colored, though sometimes the urine appears normal … See more Factors that may increase bladder cancer risk include: 1. Smoking.Smoking cigarettes, cigars or pipes may increase the risk of bladder cancer by causing harmful chemicals to accumulate in the urine. When you … See more Bladder cancer begins when cells in the bladder develop changes (mutations) in their DNA. A cell's DNA contains instructions that tell the cell what to do. The changes tell the … See more Although there's no guaranteed way to prevent bladder cancer, you can take steps to help reduce your risk. For instance: 1. Don't smoke.If you don't smoke, don't start. If you smoke, talk to your doctor about a … See more WebApr 15, 2024 · Abstract Muscle-invasive bladder cancers are characterized by their distinct expression of luminal and basal genes, which could be used to predict key clinical features such as disease progression and overall survival. Transcriptionally, FOXA1, GATA3, and PPARG are shown to be essential for luminal subtype-specific gene regulation and … smart goals for accountability