WebMar 17, 2024 · Chit Fang Cheok. Principal Investigator. Institute of Molecular and Cell Biology. View articles. Chit Fang received her B.Sc (Hons) from Imperial College London and her DPhil degree from the University of Oxford. While at the Molecular Oncology group in Cancer Research UK (Oxford), she studied the role of a causative mutation in BLM in … WebChit Fang received her B.Sc (Hons) from Imperial College London and her DPhil degree from the University of Oxford. While at the Molecular Oncology group in Cancer …
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WebMar 1, 2014 · It is shown that inhibition of RIF1 expression by small interfering RNA led to defective homologous recombination-mediated DNA double-strand break repair and sensitized cancer cells to camptothecin or staurosporine treatment, suggesting that Rif1 encodes an anti-apoptotic factor required for DNA repair and is a potential target for … WebChit Fang Cheok. The protein p53 regulates the fate of cells [1]. Blagosklonny and his colleagues [2], and others [3] in a series of studies have been using the non-genotoxic p53 activator, Nutlin... crystal boba tea
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WebChit Fang Cheok; Inactivation of the p53 gene is a key driver of tumorigenesis in various cancer cohorts and types. The quest for a successful p53-based therapy that holds the promise of treating ... WebApr 5, 2016 · p53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest, senescence, and apoptosis. We discovered a function of p53 in preventing conflicts between transcription and replication, independent of its canonical roles. p53 deficiency sensitizes cells to Topoisomerase (Topo) II inhibitors, resulting in DNA … WebDec 12, 2024 · Chit Fang Cheok. Cancer and Stem Cell Biology Program, Duke–NUS Graduate Medical School, 8 College Road, Singapore, 169857, Singapore. Ramesh Kumar. Authors. Ramesh Kumar. View author … dvine beauty tyrrelstown