Cisplatin and kidney injury

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August undefined, 2024

WebMay 18, 2024 · Vascular injuries caused by cisplatin may be due to an atypical hemolytic uremic syndrome. 58 Renal vascular pathology shows concentric subintimal thickening of small arteries and arterioles, with loose mucoid-appearing material and fibrin thrombi in afferent arterioles and glomerular capillaries. 58 From the age of 18 years to 80 years, … WebA known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates …

Mechanisms of Cisplatin-Induced Acute Kidney Injury ... - PubMed

WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. WebApr 5, 2024 · Cisplatin causes neuropathy, cardiotoxicity, ototoxicity, hepatotoxicity, and nephrotoxicity [ 4–7 ]. Acute kidney injury (AKI) represents a noticeable adverse effect of cisplatin therapy as cisplatin accumulates in the kidney and causes a decline in vascular, glomerular, and tubular functions [ 4–7 ]. flare of lightning

Cisplatin-induced renal toxicity in elderly people

WebOct 15, 2024 · Cisplatin administration for acute kidney injury (AKI) leads to serious side effects and there is a higher risk of death [2]. In clinical practice, the main causes of AKI are infections, nephrotoxic drugs, diabetes, hypertension, sepsis and cardiovascular disease. WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular … WebApr 25, 2014 · A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often … flare of light synonym

PSTPIP2 inhibits cisplatin-induced acute kidney injury by …

Developing better mouse models to study cisplatin-induced kidney injury …

WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular … WebApr 14, 2024 · For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [29 ... . Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury. PLoS ONE 2024, ... can states tax the federal governmentWebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … can states tax roth ira distributions

"WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the complex pathogenesis of kidney … " - Cisplatin and kidney injury

Cisplatin and kidney injury

IJMS Free Full-Text Pro-Inflammatory Signalling PRRopels Cisplatin …

WebOct 22, 2024 · Dose-dependent progression to CKD by repeated cisplatin administration. In order to evaluate the kidney injury after repeated injection of different doses of cisplatin in vivo, male wild type mice ... WebDec 12, 2024 · Cell Death & Disease - PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cells Skip to main content …

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WebDec 2, 2024 · It is well recognized that cisplatin may induce acute kidney injury (AKI) during chemotherapy. However, recent work further indicates that cisplatin treatment may have long-term effects in kidneys resulting in the development or progression of chronic kidney disease (CKD) in treated patients ( 16 ). WebMay 8, 2024 · Additionally, patients who did not receive mannitol with cisplatin were 2.6 times more likely to develop acute kidney injury. Implications for Practice. Overall, Duffy et al. said that the evidence regarding interventions to prevent nephrotoxicity is still limited and unable to support best practices for patients. They called for additional ...

WebNational Center for Biotechnology Information WebIntroduction. Cisplatin is an extensively used chemotherapeutic drug for various types of human cancer. However, 20–35% of patients are diagnosed with renal dysfunction after cisplatin intervention, even after hydration pretreatment. 1 Acute kidney injury (AKI) is the primary manifestation of cisplatin-induced nephrotoxicity. The mechanisms include DNA …

WebNov 3, 2024 · The kidney injury caused by cisplatin can present in a variety of ways. As it was clearly proved in some researches, the most serious and common damage induced by cisplatin is acute kidney injury (AKI) which occurs in 20–30% of patients, following a single injection of cisplatin [ 4 ]. WebFeb 18, 2024 · The ability of cisplatin (cis-diamminedichloroplatinum II) toxicity to induce acute kidney injury (AKI) has attracted attention and concern for a long time, but the molecular mechanism of...

WebThe most direct evidence for NLRP3 involvement in CIN comes from NLRP3-specific inhibitor experiments that showed protection against CIN. Cisplatin-induced kidney injury was mitigated by chemical inhibition of NLRP3 with MCC950, demonstrating the role of the NLRP3 inflammasome in exacerbating CIN directly .

WebMay 8, 2024 · Interindividual variability in kidney injury associated with cisplatin is greater than that explained by pharmacokinetic differences among patients. 2 What, if anything, … can states challenge executive ordersWebNov 1, 2024 · Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal tubular cells. Mitophagy is a form of... flare of diverticulitis cksWebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). flare of myasthenia gravis flare of msWebDec 21, 2024 · myo -inositol; cisplatin; acute kidney injury; ferroptosis 1. Introduction Acute kidney injury (AKI) is an ominous clinical–pathologic state associated with the abrupt loss of renal functions and consequential complications. It is estimated that more than 20–50% of hospitalized patients are affected by various episodes of AKI [ 1 ]. can states wage warWebApr 12, 2024 · Surgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective … can states trade with other countriesWebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well … flare of oa