High affinity copper uptake protein

WebProtein High affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence … WebThe redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. However, little is known …

SLC31A1 Antibody (CPTC-SLC31A1-1) - DSHB

Web12 de abr. de 2024 · To overcome this challenge, bacteria synthesize high-affinity iron-binding molecules called siderophores, which are recognized by specific transporters on the cell surface. Trojan horse antibiotics have evolved to hijack these transporters for uptake across the outer membrane (OM). Web12 de out. de 2012 · The Ctr1 gene encodes a multispanning plasma membrane protein of 460 amino acids and is a necessary factor in high affinity copper uptake and supplies copper for all known copper-dependent physiological processes (Georgatsou et al., 1997, Sinani et al., 2007, Nakagawa et al., 2010). ina garten adult mac and cheese recipe https://bloomspa.net

SLC31A1 solute carrier family 31 member 1 [ (human)]

WebHigh-affinity, saturable copper transporter involved in dietary copper uptake. go to UniProt 3D viewer pLDDT corresponds to the model’s prediction of its score on the local … Webencode a high affinity copper uptake process and was found to be 29% identical at the primary structure level with Ctr1 from yeast. The human protein was, however, substantially smaller than the yeast protein, being composed of 190 amino acids as compared with 406 amino acids (see Fig. 1). hCTR1 is on the Web16 de mar. de 2010 · Copper and iron are essential elements employed in pathways that are conserved in all kingdoms of life. In eukaryotes, several interdependent connections between copper and iron homeostasis have been described previously ().For example, high-affinity iron uptake in Saccharomyces cerevisiae is mediated by multicopper … ina garten air fryer recipes

Tmac1, a transcription factor which regulated high affinity copper ...

Category:Full article: Targeting copper metabolism to defeat KRAS-driven ...

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High affinity copper uptake protein

High affinity binding between copper and full-length prion protein ...

WebThese high-affinity copper transporters exist in all eukaryotes and their discovery has provided new insights into how cells acquire and regulate this essential nutrient. The … WebHuman CTR1 is a high-affinity copper transporter that also mediates the uptake of the anticancer drug cisplatin by largely unknown transport mechanisms. Here we report the 6 …

High affinity copper uptake protein

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WebIt was shown that a gene, CTR1, encoded a multispanning plasma membrane protein that was specifically required for high affinity copper transport into yeast.The CTR1 gene product is a protein composed of 406 amino acid residues. A second high affinity copper uptake protein, encoded by the CTR3 gene, was subsequently identified. The two gene … Web1 de abr. de 2024 · The CTR1 gene of Saccharomyces cerevisiae encodes a protein required for high affinity copper uptake. The protein is expressed on the plasma membrane, is heavily glycosylated with O-linkages, and ...

Web21 de mar. de 2024 · High Affinity Copper Uptake Protein 1 3 4 Copper Transporter 1 3 4 Solute Carrier Family 31 (Copper Transporters), Member 1 3 Copper Transport 1 Homolog 3 External Ids for SLC31A1 Gene HGNC: 11016 NCBI Entrez Gene: 1317 Ensembl: ENSG00000136868 OMIM®: 603085 UniProtKB/Swiss-Prot: O15431 Previous HGNC … Web5 de jun. de 2001 · Previously, we described a human gene (CTR1;SLC31A1) that encodes a high-affinity copper-uptake protein and hypothesized that this protein is required for …

Web8 de abr. de 2024 · HIGHLIGHTS. who: Nina Salustros from the (UNIVERSITY) have published the research: Structural basis of ion uptake in copper-transporting P1B-type ATPases, in the Journal: (JOURNAL) of 16/08/2024 what: Transport and regulation mechanism Based on detailed analyses of the structurally determined E1 state and … WebProtein target information for High affinity copper uptake protein 1 (Norway rat). Find diseases associated with this biological target and compounds tested against it in …

Webhigh-affinity copper uptake (17, 18). Based on its copper-transporting function in a yeast assay, its sequence similarity to the yeast high-affinity copper uptake protein, and its ubiquitous expression, we hypothesized that CTR1 is required for copper uptake in mammalian cells (4). Indeed two recent studies, involving 64Cu uptake (19) and ...

Web27 de mar. de 2024 · The high-affinity Cu transporter Ctr1 (K m ≈ 2 μM) 4, an integral membrane protein localized to the plasma membrane and endosomal vesicles, … ina garten and husband divorceWebCatalog FieldsAntigen: High affinity copper uptake protein 1Available to For-Profits: YesAntigen Species: HumanHybridoma Cells Available (Non-Profit): NoIsotype: MIgG2bDepositor: Clinical Proteomics Technologies for CancerHost Species: mouseAntigen Sequence: Positive Tested Species Reactivity: HumanDepositors Institution: National … incent holdingsWebAlternate Antibody Name: Alternate Gene Names: Solute Carrier Family 31 (Copper Transporter), Member 1; COPT1; CTR1; Copper Transporter 1; Solute Carrier Family 31 … ina garten and jeffrey youngHigh affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene. Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, … Ver mais In 2024, a new autosomal-recessive disease was discovered that is caused by mutations of the CTR1 gene. The disease is characterized by profound deficiency of copper in the central nervous system and presents with … Ver mais • Solute carrier family Ver mais • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". … Ver mais incent holdings pty ltdWebCTR1, high affinity copper uptake protein 1; ATP7A, copper-transporting ATPase 1; CCO, cytochrome C oxidase; ATOX1, copper transport protein ATOX1; KRAS, Kirsten rat sarcoma 2 viral oncogene homolog. Display full size. Figure 1. KRAS-driven colorectal cancer (CRC) cells are addicted to copper metabolism. incent itWebProtein target information for High affinity copper uptake protein 1 (house mouse). Find diseases associated with this biological target and compounds tested against it in … ina garten and faith hillWebWe ascertain the ability of these proteins to functionally complement and transport copper in the corresponding Saccharomyces cerevisiae high-affinity copper transport mutant. The specific expression pattern of the Arabidopsis COPT1–5 mRNA in different tissues was analyzed by RT-PCR. incent offer affiliate network