Small highly active dnas that hydrolyze dna

Webb6 juni 2013 · DNA phosphoester bonds are exceedingly resistant to hydrolysis in the absence of chemical or enzymatic catalysts. This property is particularly important for … Webb14 okt. 2024 · DNA nanosponges are an emerging attractive type of nanocarriers for targeted therapeutics due to their ability to integrate diverse molecules, including DNA …

DNAs catalyzing DNA nanoconstruction - ScienceDirect

Webbför 2 dagar sedan · Herein, based on the mobility change of DNA in denaturing gels, we develop a selection strategy to discover a series of 40-45 nt small DNAs that can bind … Webb6 juni 2013 · The identification of small DNA-cleaving deoxyribozymes that function with high speed under mild reaction conditions should permit their use in various … greatway office scarborough https://bloomspa.net

Sci-Hub Small, Highly Active DNAs That Hydrolyze DNA. Journal …

WebbThe development of a simple DNA sensor based on DNAzyme and PCR and aimed at the detection of low concentrations of zinc (II) ions, which showed sensitivity (10 nM) and high specificity for zinc ion detection is described. AbstractThe development of a simple sensor (9NL27-Zn) based on DNAzyme and PCR and aimed at the detection of low … WebbNatural DNA sequences conforming to the class I consensus sequence and structure were found that undergo hydrolysis under selection conditions (2 mM Zn2+, pH 7), which … Webb16 maj 2013 · highly-active deoxyribozymes that catalyze DNA hydrolysis indeed can be isolated. However, the precise sequence at the cleavage site and its structural … florida man bit in head by alligator

(PDF) Small, highly active DNAs that hydrolyze DNA. (2013)

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Small highly active dnas that hydrolyze dna

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Webb31 maj 2024 · DNA-hydrolyzing DNAs represent an attractive type of DNA-processing catalysts distinctive from the protein-based restriction enzymes. The innate DNA property has enabled them to readily join DNA-based manipulations to promote the development of DNA biotechnology. Webb5 juni 2013 · Natural DNA sequences conforming to the class I consensus sequence and structure were found that undergo hydrolysis under selection conditions (2 mM Zn(2+), …

Small highly active dnas that hydrolyze dna

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WebbNatural DNA sequences conforming to the class I consensus sequence and structure were found that undergo hydrolysis under selection conditions (2 mM Zn2+, pH 7), which … WebbSmall, highly active DNAs that hydrolyze DNA. J. Am. Chem. Soc. 2013; 135: 9121-9129. Crossref; PubMed; Scopus (94) Google Scholar; of I-R3 in DNA cleavage. Besides I-R3, other metal-dependent deoxyribozymes that cleave a RNA bond have also been successfully engineered as molecular triggers to actively generate nanoholes in DNA origami ...

Webbhydrolyzing DNAs is further highlighted by the fact that it has been relatively straightforward to create deoxyribozymes that promote DNA cleavage by oxidative 4 or … WebbSmall, highly active DNAs that hydrolyze DNA. Article. Full-text available. May 2013; J AM CHEM SOC; Hongzhou Gu; Kazuhiro Furukawa; Zasha Weinberg; Daniel F Berenson; Ronald R Breaker;

Webb27 jan. 2011 · Small, highly active DNAs that hydrolyze DNA. Hongzhou Gu, K. Furukawa, Z. Weinberg, Daniel F. Berenson, R. Breaker; Biology. ... Using in vitro selection, this work has identified deoxyribozymes that sequence-specifically hydrolyze DNA with multiple turnover and rate enhancement of 108 ... WebbMembers of the single-stranded DNA pool contain two 15 nt primer binding sites (5′ and 3′ termini) and two 50 nt random-sequence domains ... Reported in... Year of Publication First Author Laboratory Title PubMed ID DOI Reaction; 2013: H Gu: R R Breaker: Small, highly active DNAs that hydrolyze DNA. 23679108: 10.1021/ja403585e: DNA cleavage ...

Webb14 okt. 2024 · Catalytic DNAs, mainly DNA/RNA-cleaving DNAs, ... with the total 17 conserved nucleotides forming a catalytic loop to site-specifically hydrolyze DNA in the loop upon the supplementation of Zn 2+ ... Small, highly active DNAs that hydrolyze DNA. J. Am. Chem. Soc., 135 (2013), pp. 9121-9129.

Webb6 okt. 2024 · Flow cytometry analysis. The MCF-7 cells (human breast tumor cell line), HeLa cells (cervical tumor cell line), and MCF-10A cells (human breast normal cell line) were seeded at a density of 2 × 10 5 per well onto a 6-well plate and cultured. When the cells reached 90% confluency, the F-ZD nanoparticles dispersed in the Opti-minimum … greatway office surreyflorida man burning booksWebb(B) Hydrolytic instability of natural DNA sequences. Trace amounts of each natural DNA (5′ 32P-labeled) were incubated at 37 °C in reaction buffer without or with 2 mM Zn2+ for 6 … florida man catches wife cheating stabbedWebbNatural DNA sequences conforming to the class I consensus sequence and structure were found that undergo hydrolysis under selection conditions (2 mM Zn2+, pH 7), which … greatway office winnipegWebb6 jan. 2016 · Nature - Both DNA and RNA molecules are foldable and can adopt conformations that exhibit catalytic activity. While the structures of various catalytic RNAs — or ribozymes — have been... florida man caught his wife cheatingWebb7 dec. 2024 · DNA nanotechnology, in particular DNA origami, enables the bottom-up self-assembly of micrometre-scale, three-dimensional structures with nanometre-precise features 1,2,3,4,5,6,7,8,9,10,11,12 ... greatway office torontoWebb6 okt. 2010 · Small, Highly Active DNAs That Hydrolyze DNA. Journal of the American Chemical Society 2013, 135 (24) , 9121-9129. DOI: 10.1021/ja403585e. Darren J. Parker, Ying Xiao, John M. Aguilar, and Scott K. Silverman . DNA Catalysis of a Normally Disfavored RNA Hydrolysis ... florida man breaks into jail to hang out